
产品描述
消化道壁具有选择性渗透性。它允许营养物质的吸收,同时为外界提供保护屏障。在患病或发炎的情况下,肠道可能会出现肠道通透性增加。这通常被称为肠漏。肠道通透性增加与某些药物、食物过敏、感染、各种肠道疾病和肠易激综合征有关。虽然消除环境和外部有害因素对于护理至关重要,但特定营养素已被证明有助于修复细胞间紧密连接并恢复最佳通透性。
L-谷氨酰胺是人类健康最知名和最重要的氨基酸之一。它不仅是谷胱甘肽生成所必需的,还被认为是巨噬细胞和淋巴细胞的主要燃料,这些细胞是正常免疫所必需的,也是消化道内壁的肠细胞的主要燃料。 L-谷氨酰胺似乎在康复期间最需要,因为肌肉谷氨酰胺水平会因巨大的压力而急剧下降。
例如,在各种压力下,补充谷氨酰胺后,人们观察到消化系统健康状况有所改善。据报道,补充谷氨酰胺后,消化系统疾病患者和服用抗病毒药物的患者腹泻和消化不良的次数减少。这些消化益处被认为是由于其在恢复紧密连接和降低肠道通透性方面的作用。
锌肌肽 (ZnC) 是元素锌和氨基酸 β-丙氨酸和组氨酸的组合,是另一种因其胃保护功能而受到广泛研究的营养素。ZnC 有助于恢复受损胃粘膜中的谷胱甘肽水平,并抑制促炎细胞因子的产生。一项研究发现,ZnC 与吲哚美辛同时给药可降低与 NSAID 使用相关的后续肠道通透性。另一项研究表明,多达 72% 的胃组织损伤患者在接受 4-8 周的 ZnC 治疗后获得了显着改善。最后,ZnC 对幽门螺杆菌具有强大的抗菌作用。例如,将 ZnC 添加到“三联疗法”(根除幽门螺杆菌的传统药物治疗)中比单独使用三联疗法更有效。
N-乙酰葡萄糖胺 (NAG) 对支持肠道内壁的特定部分(称为粘蛋白层)非常重要。在健康的胃肠道中,粘蛋白充当微生物群和上皮内壁之间的屏障。然而,这种屏障在疾病状态下会变薄或有效分解,从而允许细菌渗透和发炎。葡萄糖胺是重建粘蛋白所必需的,并且已证明 NAG 优先融入肠道粘蛋白层,而其他葡萄糖胺来源(如硫酸葡萄糖胺)则不然。最重要的是,NAG 可改善粘蛋白厚度和临床症状。最后,在讨论消化道内壁的愈合过程时,必须提到益生菌。芽孢杆菌等产芽孢益生菌因其即使在最恶劣的环境中也能生存的能力而闻名。事实上,芽孢杆菌菌株的孢子可以在极端温度变化和 pH 值变化的情况下以休眠状态存活数年。孢子发芽和激活的适当环境发生在小肠中,因为小肠中糖、氨基酸和嘌呤含量丰富。
一旦发芽和激活,凝结芽孢杆菌就可以通过产生多种酶和短链脂肪酸来促进消化、增加营养吸收和减少炎症。此外,凝结芽孢杆菌通过竞争资源和阻止致病菌的生长,提供天然的抗菌作用。它通过在肠道中创造厌氧和酸性环境来实现这一点,这使得肠道不适合各种病原体生存,并为有益细菌(如乳酸杆菌和双歧杆菌)的繁殖提供理想条件
总而言之,凝结芽孢杆菌有助于通过改善微生物群的多样性、组成和代谢功能来促进有益的肠道菌群。临床研究表明,凝结芽孢杆菌 IS-2 菌株可有效治疗成人肠易激综合征 (IBS) 和功能性腹痛,以及儿童肠易激综合征和便秘。
GI Matrix 含有基于证据的 L-谷氨酰胺、锌肌肽、n-乙酰葡萄糖胺和凝结芽孢杆菌混合物,旨在共同减少消化道的炎症和肠道通透性。每种营养素均以经过临床验证的剂量提供,以支持排便规律、控制肠易激综合征症状并促进肠道菌群健康。GI Matrix 无味、易溶,仅用罗汉果提取物稍微加甜以提高依从性。每盒 60 份,以全日剂量提供 30 天的供应量。
特点:
一种基于证据的混合物,由 L-谷氨酰胺、N-乙酰葡萄糖胺、锌肌肽和产芽孢杆菌凝结芽孢杆菌 IS-2 组成,旨在改善肠道完整性和肠道通透性。无味,略带甜味。
- 旨在减少消化道炎症和肠道通透性
- L-谷氨酰胺作为肠细胞的主要燃料,有助于恢复消化道内壁的紧密连接
- 锌肌肽具有抗幽门螺杆菌特性和胃保护能力
- N-乙酰葡萄糖胺因其能够支持肠道的粘蛋白层而被添加
- 凝结芽孢杆菌 IS-2,一种产芽孢细菌,因其能够治疗儿童的肠易激综合征和功能性腹痛以及成人的肠易激综合征和便秘而被添加
- 不含麸质、大豆和乳制品
成分:
上述计量单位:
每勺
成分数量
凝结芽孢杆菌 IS-2 10 亿菌落形成单位
L-谷氨酰胺 4.5 克
N-乙酰葡萄糖胺 500 毫克
锌 L-肌肽37.5 毫克
非药用成分:
罗汉果提取物、麦芽糊精。
使用说明和注意事项
适应症:有助于在身体压力过后维持消化系统和免疫系统的健康。益生菌来源有助于促进肠道菌群健康。有助于减轻成人肠易激综合征患者的腹部不适、腹胀和排便不尽感等症状。有助于缓解与功能性便秘相关的症状。
使用说明:成人 - 每天 2 次,每次 1 勺,随餐服用或按照医疗保健专业人员的指示服用。服用抗生素、其他药物或天然保健产品前或后至少 2-3 小时服用。
注意事项:如果安全密封破损,请勿使用。使用前请咨询医疗保健专业人员,尤其是如果您怀孕或哺乳,或者您发烧、呕吐、血性腹泻或严重腹痛。如果出现消化不良症状(例如腹泻)、症状恶化和/或持续超过 3 天,请停止使用并咨询医疗保健专业人员。请将本品放在儿童接触不到的地方。
禁忌症:如果您患有免疫功能低下的情况(例如艾滋病、淋巴瘤、接受长期皮质类固醇治疗的患者),请勿使用本产品。
已知不良反应:补锌可能导致铜缺乏。
Product Description
The digestive tract wall is selectively permeable. It allows the absorption of nutrients while simultaneously providing a protective barrier to the outside world. In cases of disease or inflammation, the gut may experience increased intestinal permeability. This is commonly known as leaky gut. Increased intestinal permeability has been linked to certain medications, food allergies, infections, various bowel diseases and irritable bowel syndrome. While removing environmental and external offending factors is integral for care, specific nutrients have been shown to help repair intercellular tight junctions and restore optimal permeability.
L-glutamine is one of the most well-known and crucial amino acids for human health. Not only is it necessary for glutathione production, it is also considered a primary fuel for macrophages and lymphocytes needed for proper immunity as well as enterocytes that line the digestive tract. L-glutamine appears to be most needed during times of convalescence, as muscle glutamine levels drop drastically due to significant stress.
Case in point, improved digestive health has been observed as a result of glutamine supplementation under a variety of stressors. Reduced diarrhea and less digestive upset have been reported in supplemented individuals with digestive disorders, and those taking antiviral medications. These digestive benefits are thought to be as a result of its role in restoring tight junctions and reducing intestinal permeability.
Zinc Carnosine (ZnC), a combination of elemental zinc and the amino acids beta-alanine and histidine, is another nutrient with extensive research for its gastroprotective capabilities. ZnC helps to restore glutathione levels in injured gastric mucosa and also to inhibit proinflammatory cytokine production. One study found that co-administration of ZnC with indomethacin decreased the subsequent gut permeability associated with NSAID use. Another study demonstrated that up to 72% of subjects with gastric tissue damage achieved remarkable improvement after 4-8 weeks of ZnC treatment. Lastly, ZnC has potent antimicrobial actions against Helicobacter pylori . For example, the addition of ZnC to “triple therapy”, the traditional pharmaceutical treatment for H. pylori eradication, is more efficacious than when compared to triple therapy alone.
N-Acetylglucosamine (NAG) is important in supporting a specific portion of the intestinal tract lining known as the mucin layer. In a healthy GI tract, mucin acts as a barrier between the microbiome and the epithelial lining. However, this barrier is thinner or effectively breaks down in disease states and allows for bacterial penetration and inflammation. Glucosamine is necessary for rebuilding mucin and NAG has been shown to be preferentially incorporated into the intestinal mucin layer compared to other glucosamine sources such as glucosamine sulphate. Most importantly, NAG improves mucin thickness and clinical symptoms. Finally, in discussing the healing process of the digestive tract lining, one must mention probiotics. Spore-forming probiotics such as Bacillus coagulans are noted for their ability to survive even in the most harsh environments. In fact, spores of bacillus strains can survive in their dormant state for years through extreme temperature changes and pH alterations. The proper setting for spore germination and activation occurs in the small intestine where sugars, amino acids and purines are widely available.
Once germinated and activated, Bacillus coagulans can promote digestion, increase nutrient absorption and reduce inflammation by producing a variety of enzymes and short-chain fatty acids. In addition, Bacillus coagulans provides a natural antimicrobial effect by competing for resources and preventing the growth of pathogenic bacteria. It does so by creating an anaerobic and acidic environment in the intestines, which makes it inhospitable for various pathogens and offers ideal conditions for beneficial bacteria to flourish, such as lactobacillus and bifidobacterium species
All in all, Bacillus coagulans helps to promote a favourable gut flora by improving the diversity, composition and metabolic function of the microbiota. Clinical studies have shown that the Bacillus coagulans IS-2 strain is effective in the treatment of irritable bowel syndrome (IBS) and functional abdominal pain in adults, as well as IBS and constipation in children.
GI Matrix contains an evidence-based blend of L-glutamine, zinc carnosine, n-acetylglucosamine and Bacillus coagulans, collectively designed to decrease inflammation and intestinal permeability in the digestive tract. Each of these nutrients is delivered in clinically validated dosages to support bowel regularity, manage symptoms of irritable bowel syndrome and promote a favourable gut flora. GI Matrix is unflavoured, easily soluble and only slightly sweetened with monk fruit extract in order to improve compliance. 60 servings per container, providing a 30-day supply at its full daily dose.
Features:
- Designed to decrease inflammation and intestinal permeability in the digestive tract
- L-glutamine acts as the primary fuel for the enterocytes and help to restore tight junctions in the digestive tract lining
- Zinc carnosine offers anti-Helicobacter pylori properties and gastroprotective capabilities
- N-acetylglucosamine is included for its ability to support the mucin layer of the intestinal tract
- Bacillus coagulans IS-2, a spore-forming bacterium is added for its ability to address IBS and functional abdominal pain in children as well as IBS and constipation in adults
- Gluten, soy and dairy-free
Ingredients:
Unit of Measure above:
Each scoop
Ingredient | Amount |
---|---|
Bacillus coagulans IS-2 | 1 billion CFU |
L-glutamine | 4.5g |
N-acetylglucosamine | 500mg |
Zinc L-carnosine | 37.5mg |
Non-Medicinal Ingredients:
Monk fruit extract, maltodextrin.
Directions & Cautions
Indications: Helps support digestive and immune system health after periods of physical stress. Source of probiotics to help promote favourable gut flora. Helps reduce the symptoms of Irritable Bowel Syndrome in adults with IBS such as abdominal discomfort, bloating and sense of incomplete evacuation. Helps relieve symptoms associated with functional constipation.
Directions for Use: Adults - Take 1 scoop, 2 times per day with food or as directed by a healthcare professional. Take at least 2-3 hours before or after antibiotics, other medications or natural health products.
Cautions: Do not use if safety seal is broken. Consult a healthcare professional prior to use especially if you are pregnant or breastfeeding or if you have a fever, vomiting, bloody diarrhoea or severe abdominal pain. Stop use and consult a healthcare professional if symptoms of digestive upset (e.g. diarrhoea) occur, worsen and/or persists beyond 3 days. Keep out of reach of children.
Contraindications: Do not use this product if you have an immune-compromised condition (e.g. AIDS, lymphoma, patients undergoing long-term corticosteroid treatment).
Known Adverse Reactions: Zinc supplementation can cause a copper deficiency.
*These statements have not been evaluated by the Food and Drug Administration. This product is not in tended to diagnose, treat, cure, or prevent any disease.
Some formulas may be slightly different outside Canada and the US.