产品描述
人体具有复杂的排毒系统，可以消除不必要的化合物，如食物垃圾副产品、物理惰性金属和日常化学品。然而，我们的排毒系统也需要调节类固醇激素，如雌激素。肝脏和消化道功能不佳，再加上过度接触外来雌激素，会导致雌激素的肝肠循环，最终形成雌激素占主导地位的状态，对身体健康产生负面影响。值得庆幸的是，已经发现了许多天然化合物可以促进适当的雌激素排毒和健康的激素代谢。
吲哚-3-甲醇 (I-3-C) 天然存在于十字花科蔬菜中，如西兰花和花椰菜，它以支持健康的雌激素代谢而闻名。I-3-C 上调 2-OHE1 的产生，2-OHE1 是雌激素的保护形式，可作为雌激素拮抗剂。另一方面，16-OHE1 具有强大的雌激素和增殖作用，可对抗 2-OHE1 的作用。研究反复表明，2-OHE1 与 16-OHE1 的比例越高，越能预防疾病，并且有利于改善雌激素占主导地位的疾病症状。I-3-C 可改善雌激素代谢物的这种比例。
大量试验表明，补充 I-3-C 可导致雌激素代谢物的这种积极转变，这对健康结果有利。例如，I-3-C 已被证明可以改善宫颈疾病女性的雌激素比例和健康结果。动物研究还发现，I-3-C 可以防止乳腺组织中不健康的细胞分化。 I-3-C 不仅能促进雌激素代谢物比例的正向变化，还能影响多种基因的表达，如肿瘤抑制基因 p53 和 BRCA1，这些基因共同支持激素敏感组织的健康分化。
I-3-C 在体内自然代谢，提供多种活性化合物，包括主要代谢物二吲哚甲烷 (DIM)。尽管关于 DIM 或 I-3-C 哪种更适合作为健康补充剂存在争议，但每种化合物都有其优势。I-3-C 为身体提供多种活性代谢物，而 DIM 似乎是一种具有强大解毒活性的主要代谢物。这两种化合物都是经过充分研究的有效治疗方法，可有效调节体内的雌激素。
D-葡萄糖酸盐或葡萄糖酸是另一种天然化合物，天然存在于橙子、胡萝卜、苹果和西兰花中，它通过使 B-葡萄糖醛酸酶失活来促进过量激素、各种毒素和致癌物的排毒。B-葡萄糖醛酸酶是由结肠微生物群产生的一种酶，可以“重新激活”之前被肝脏中和的化合物，防止这些毒素在体内再循环。动物研究发现，大剂量的 D-葡萄糖酸钙可以将血液中的雌激素水平降低高达 23%，并对脂质平衡产生有利影响。简而言之，D-葡萄糖酸钙是最广为人知的天然 B-葡萄糖醛酸酶抑制剂之一，也是最安全输送 D-葡萄糖酸盐的形式。
最后，萝卜硫素葡萄糖苷 (SGS) 是一种天然化合物，与 I-3-C 和 DIM 一样，也存在于西兰花和十字花科蔬菜中。大量临床试验支持其通过去除外来生物和强力诱导肝脏中的 2 期解毒酶来促进健康的细胞分化。例如，SGS 已被证明可以降低黄曲霉毒素暴露对肝脏组织的致癌作用。SGS 还通过抑制核因子 κB (NFkB)、前列腺素 E2 和肿瘤坏死因子-α (TNF-a) 具有抗炎作用，它可以降低乳腺组织中的雌激素受体表达，并且对幽门螺杆菌、化脓性链球菌和金黄色葡萄球菌等病原体具有抗菌活性。
每天服用三粒胶囊，Cyto-Matrix 的 Estro Matrix 含有 200 毫克 I-3-C、100 毫克 DIM、1500 毫克 D-葡萄糖酸钙和 100 毫克萝卜硫素。总之，Estro Matrix 提供基于证据的协同成分剂量，通过适当的雌激素代谢提供有针对性和持续性的激素支持。
特点：
基于证据的 D-葡萄糖酸钙、DIM、I-3-C 和萝卜硫素混合物，通过肝脏和消化系统排毒支持适当的雌激素代谢。
- 通过改善外来化合物的解毒作用和支持肝功能，可促进雌激素的正常代谢、雌激素占主导地位的健康状况的症状控制以及乳腺和宫颈组织的健康细胞分化
- D-葡萄糖酸钙可作为β-葡萄糖醛酸酶抑制剂，防止雌激素的肠肝循环
- I-3-C 和 DIM 促进 2-OHE1 的产生，2-OHE1 是雌激素的保护形式，可在体内充当雌激素拮抗剂
- 萝卜硫素硫代葡萄糖苷可有效上调第 2 阶段解毒酶，并支持清除外来化合物和各种致癌物
成分：
上述计量单位：每个胶囊
成分量
DIM 33.3 毫克
吲哚-3-甲醇 66.7 毫克
BroccoPhane®（豆芽，甘蓝（Brassica oleracea var. italica）33.3mg
D-葡萄糖酸钙（蔗糖酸钙）500mg
非药用成分：植物级硬脂酸镁、微晶纤维素。胶囊：羟丙甲纤维素。
使用说明和注意事项
适应症：有助于促进健康的雌激素平衡，减少与复发性乳房疼痛相关的症状的严重程度和持续时间。提供抗氧化剂，有助于防止自由基引起的细胞损伤。
使用说明：成人 - 每天服用 2 粒胶囊，或按照医疗保健专业人员的指示服用。
注意事项：如果安全密封破损，请勿使用。使用前请咨询医疗保健专业人员，特别是如果您正在服用其他药物或天然保健产品，并排除荷尔蒙失调的严重原因的诊断。如果您正试图怀孕、患有肝脏疾病或出现雌激素水平低的症状（如关节疼痛、情绪变化、性欲变化、潮热、盗汗、阴道干燥或月经不调），或者出现肝脏相关症状（如眼睛和/或皮肤发黄、尿液呈深色、腹痛、黄疸）或雌激素水平低的症状，请咨询医疗保健专业人员。如果乳房疼痛反复发作或恶化，请咨询医疗保健专业人员。
禁忌症：如果您正在怀孕或哺乳，请勿使用。
Product Description
The human body is designed with intricate detoxification systems to eliminate unnecessary compounds such as food waste byproducts, physically inert metals and everyday chemicals. However, our detoxification systems are also needed to regulate steroid hormones such as estrogen. Suboptimal liver and digestive tract function, in combination with excessive exposure to xenoestrogens, can lead to enterohepatic recirculation of estrogens and ultimately create an estrogen- dominant state with negative health implications for the body. Thankfully, a number of natural compounds have been identified to promote proper estrogen detoxification and healthy hormone metabolism.
Indole-3-carbinol (I-3-C) is naturally found in cruciferous vegetables such as broccoli and cauliflower and it is well-known for its ability to support healthy estrogen metabolism. I-3-C upregulates the production of 2-OHE1, the protective form of estrogen that acts as an estrogen antagonist. 16-OHE1, on the other hand, has potent estrogenic and proliferative effects that oppose the action of 2-OHE1. Research has repeatedly shown that a higher ratio of 2-OHE1 to 16-OHE1 is protective against disease and desirable for improving symptoms in estrogen dominant conditions. I-3-C improves this ratio of estrogen metabolites.
Numerous trials have shown that this positive shift in estrogen metabolites, as a result of I-3-C supplementation, is advantageous for health outcomes. For example, I-3-C has been shown to improve estrogen ratios and health outcomes in women with cervical disease. Animal studies have also found that I-3-C can prevent unhealthy cellular differentiation in breast tissue. Not only does I-3-C promote a positive estrogen metabolite ratio, but it additionally influences the expression of multiple genes, such as tumor-suppressing gene p53 and BRCA1, that collectively support the healthy differentiation of hormonally sensitive tissues.
I-3-C is naturally metabolized in the body to provide multiple active compounds, including the predominant metabolite diindolylmethane (DIM). Although debate exists regarding whether DIM or I-3-C is most beneficial as a health supplement, each compound has its advantages. I-3-C provides the body with many active metabolites, while DIM appears to be a primary metabolite with a potent detoxification activity. Both compounds are well-researched and effective treatments for the proper regulation of estrogens in the body.
D-glucarate, or glucaric acid, is another natural compound found naturally in oranges, carrots, apples and broccoli, and it promotes the detoxification of excess hormones, various toxins and carcinogens by deactivating B-glucoronidase. B-glucoronidase is an enzyme produced by colonic microflora that can ‘reactivate’ compounds that had previously been neutralized by the liver, preventing the recirculation of these toxins in the body. Animal studies have found that large doses of calcium-D-glucarate can reduce estrogen levels in the blood by up to 23% and also favorably impact lipid balance. Quite simply, calcium-D-glucarate is one of the best known natural B-glucoronidase inhibitors and the best studied form to safely deliver D-glucarate.
Finally, sulphoraphane glucosinolate (SGS) is a naturally occurring compound that, like I-3-C and DIM, is also found in broccoli and cruciferous vegetables. Numerous clinical trials support its use in promoting healthy cellular differentiation through the removal of xenobiotics and powerful induction of phase 2 detoxification enzymes in the liver. For example, SGS has been shown to reduce the carcinogenic effects of aflatoxin exposure on liver tissue. SGS also has anti-inflammatory actions through the inhibition of nuclear factor kappaB (NFkB), prostaglandin E2 and tumor necrosis factor-alpha (TNF-a), it can reduce estrogen receptor expression in breast tissue and it has antimicrobial activity against pathogens such as H. pylori, S. pyogenes and S. aureus.
At three capsules per day, Cyto-Matrix’s Estro Matrix contains 200mg of I-3-C, 100mg of DIM, 1500mg of Calcium-D-Glucarate and 100mg of sulforaphane. Collectively, Estro Matrix provides evidence-based dosages of synergistic ingredients to offer targeted and ongoing hormonal support through the proper metabolism of estrogens.
Features:
An evidence-based blend of Calcium-D-Glucarate, DIM, I-3-C and Sulforaphane to support proper estrogen metabolism through liver and digestive detoxification.
- Indicated for the proper metabolism of estrogen, symptomatic control in estrogen-dominant health conditions and healthy cellular differentiation of breast and cervical tissues, through improved xenobiotic detoxification and supported liver function
- Calcium-D-glucarate acts as a Beta-glucoronidase inhibitor to prevent the enterohepatic recirculation of estrogens
- I-3-C and DIM promote the production of 2-OHE1, the protective form of estrogen that acts as an estrogen antagonist within the body
- Sulforaphane glucosinolate powerfully upregulates phase 2 detoxification enzymes and supports the removal of xenobiotics and various carcinogens
Ingredients:
Unit of Measure above: Each capsule
| Ingredient | Amount |
|---|---|
| DIM | 33.3mg |
| Indole-3-Carbinol | 66.7mg |
| BroccoPhane® (sprouts, Brassica oleracea var. italica) | 33.3mg |
| Calcium D-Glucarate (calcium saccharate) | 500mg |
Non-Medicinal Ingredients: Vegetable-grade magnesium stearate, microcrystalline cellulose. Capsule: hypromellose.
Directions & Cautions
Indications: Helps to promote healthy estrogen balance and reduce the severity and duration of symptoms associated with recurrent breast pain. Provides antioxidants that help protect against cell damage caused by free radicals.
Directions for Use: Adults - Take 2 capsules, once per day or as directed by a healthcare professional.
Cautions: Do not use if safety seal is broken. Consult a healthcare professional prior to use, especially if you are taking other medications or natural health products and to exclude the diagnosis of a serious cause of hormonal imbalance. Consult a healthcare professional if you are attempting to conceive, have a liver disorder or symptoms of low estrogen (such as joint pain, mood changes, changes in libido, hot flashes, night sweats, vaginal dryness or irregular menstruations) or if you develop liver-related symptoms (e.g. yellowing of the eyes and/or skin, dark urine, abdominal pain, jaundice) or symptoms of low estrogen. If recurrent breast pain persists or worsen, consult a healthcare professional.
Contraindications: Do not use if you are pregnant or breastfeeding.
*These statements have not been evaluated by the Food and Drug Administration. This product is not in tended to diagnose, treat, cure, or prevent any disease.
Some formulas may be slightly different outside Canada and the US.